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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DKC1
All Species:
26.36
Human Site:
T496
Identified Species:
41.43
UniProt:
O60832
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.14
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O60832
NP_001354.1
514
57674
T496
P
G
D
G
D
S
D
T
T
K
K
K
K
K
K
Chimpanzee
Pan troglodytes
XP_521345
595
65925
T577
P
G
D
G
D
S
D
T
T
K
K
K
K
K
K
Rhesus Macaque
Macaca mulatta
XP_001090867
597
66468
T579
P
G
D
G
D
S
D
T
T
K
K
K
K
K
K
Dog
Lupus familis
XP_549382
517
57997
S500
P
A
D
G
D
S
D
S
A
R
K
K
K
K
K
Cat
Felis silvestris
Mouse
Mus musculus
Q9ESX5
509
57483
T492
T
G
D
G
D
N
D
T
T
K
K
K
K
K
K
Rat
Rattus norvegicus
P40615
509
56597
D491
A
A
E
D
G
D
G
D
A
T
R
K
K
K
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514686
519
58453
S502
S
M
D
V
G
S
D
S
T
K
K
K
K
K
K
Chicken
Gallus gallus
Q5ZJH9
516
58132
S497
Q
V
E
V
I
S
E
S
S
A
K
K
K
K
K
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_001028279
506
56658
S488
E
E
T
E
V
T
E
S
A
K
K
K
K
K
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
O44081
508
56812
E488
E
E
E
A
E
P
V
E
K
E
K
K
K
K
K
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
O17919
445
50192
K429
E
E
E
E
A
P
K
K
K
S
K
K
S
K
K
Sea Urchin
Strong. purpuratus
XP_001187533
541
60439
K517
E
S
L
A
E
T
P
K
S
E
K
K
K
K
K
Poplar Tree
Populus trichocarpa
XP_002323264
482
54054
G466
E
A
A
T
I
E
N
G
K
A
D
G
E
A
D
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9LD90
565
63008
K546
S
A
A
E
K
S
E
K
K
K
K
K
K
D
K
Baker's Yeast
Sacchar. cerevisiae
P33322
483
54686
K459
K
K
D
K
K
E
K
K
E
K
K
E
K
K
R
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
85.3
85.5
89.9
N.A.
90
83.2
N.A.
85.3
81.4
N.A.
74.7
N.A.
64.7
N.A.
58.7
64.8
Protein Similarity:
100
85.3
86
93.6
N.A.
93.1
90.8
N.A.
88.8
89.9
N.A.
85.4
N.A.
77.6
N.A.
71.4
77
P-Site Identity:
100
100
100
73.3
N.A.
86.6
26.6
N.A.
66.6
40
N.A.
40
N.A.
33.3
N.A.
26.6
33.3
P-Site Similarity:
100
100
100
86.6
N.A.
93.3
40
N.A.
73.3
66.6
N.A.
60
N.A.
53.3
N.A.
33.3
60
Percent
Protein Identity:
61.2
N.A.
N.A.
57.5
57.9
N.A.
Protein Similarity:
76.4
N.A.
N.A.
73.4
71.9
N.A.
P-Site Identity:
0
N.A.
N.A.
40
33.3
N.A.
P-Site Similarity:
13.3
N.A.
N.A.
46.6
46.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
27
14
14
7
0
0
0
20
14
0
0
0
7
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
47
7
34
7
40
7
0
0
7
0
0
7
7
% D
% Glu:
34
20
27
20
14
14
20
7
7
14
0
7
7
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
27
0
34
14
0
7
7
0
0
0
7
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
14
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
7
7
0
7
14
0
14
27
27
54
87
87
87
87
87
% K
% Leu:
0
0
7
0
0
0
0
0
0
0
0
0
0
0
0
% L
% Met:
0
7
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
7
7
0
0
0
0
0
0
0
0
% N
% Pro:
27
0
0
0
0
14
7
0
0
0
0
0
0
0
0
% P
% Gln:
7
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
7
7
0
0
0
7
% R
% Ser:
14
7
0
0
0
47
0
27
14
7
0
0
7
0
0
% S
% Thr:
7
0
7
7
0
14
0
27
34
7
0
0
0
0
0
% T
% Val:
0
7
0
14
7
0
7
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _